Biotechnology · San Francisco

Developing the world's first therapeutics to heal the blood-brain barrier.

Reservoir Neuroscience is an early-stage biotechnology company building a new class of therapy designed to restore the brain's protective barrier — opening a fundamentally new approach to treating neurological disease.

The platform

Targeting the barrier itself — not working around it

The blood-brain barrier is the brain's first line of defense. When it fails, the consequences reach across nearly every neurological condition. Reservoir is building therapeutics that heal the barrier's integrity — the first approach of its kind.

Healing, not just crossing

A therapeutic designed to repair the barrier — addressing the root, not routing around it.

A new mechanism

Targeting a pathway others have not, with the potential to apply broadly across CNS disease.

Built to translate

Early-stage discovery focused on a clear path toward the clinic and meaningful patient impact.

Why it matters

The brain's gatekeeper

The blood-brain barrier protects the brain from everything it shouldn't see. When its integrity breaks down, disease follows. Restoring that barrier is one of the most direct, under-addressed levers in neurology.

#1
Approach of its kind — no approved therapy heals the barrier
Broad
Potential reach across CNS conditions tied to barrier dysfunction
New
Mechanism not previously commercialized
Team & location

Built by people who take the science seriously

Aaron Friedman
Co-founder & CEO
Leading Reservoir from inception, focused on turning the blood-brain barrier thesis into a clinical program.
Vlad Senatorov
Co-founder
Co-founding scientist driving the platform's early development.
San Francisco
665 3rd Street, Suite 250, CA 94107
Milestones

A clear-eyed path forward

Platform formation

Core thesis defined and team assembled around the blood-brain barrier mechanism.

Development underway

Early-stage discovery work progressing toward preclinical validation.

Path to clinic

Building the roadmap from discovery toward first-in-human studies.

Interested in what Reservoir is building?

For scientists, investors, and partners exploring the blood-brain barrier as a therapeutic frontier.